小中大
传统上的疫苗，有很多预测方法，对于多糖疫苗，却只是在探索过程中。
糖表位有自己的一些特点，比如刚性（糖分子通常有不同的glycoform），Molecular dynamics simulations in explicit solvent using as initial configurations the structures predicted by our algorithm show that the histo-blood group epitopes in these sugars are relatively rigid and that the whole family of oligosaccharides derives its conformational variability almost exclusively from their common linkage (beta-D: -GlcNAc-(1-->3)-beta-D: -Gal) which can exist in two distinct conformational states.[PMID18953494]
对于偶联conjugate的糖疫苗，载体蛋白或者肽的表位预测与传统的预测方法是一致的。[PMID: 7532630]
