小中大
这种现象我们组也遇到过，我不知道你作的什么药，如果是金属类的，这并不奇怪，比如有些过渡金属，稀土类元素，还有重金属，比如铂，还有砷，这些大部分都被认为是有毒的， 但是，在低剂量的时候反而有促进细胞增殖的效应，有人把它称作：Hermesis
基本解释可以看看这段引文：
First, numerous results show that activity-toxicity duality is dose-dependent. Recently, it has been found that several toxic metals exhibit a growth-promoting effect in very low concentrations (hormesis) and display toxicity at higher doses. Formerly, the growth-concentration relation for an essential element was represented by a bell-shaped curve (Figure 1a) and that of a toxic element by the right half of the curve. Nowadays, it is preferable to represent the growth-dose dependence of a toxic element by the type of curve given in Figure 1b. The latter is similar to Figure 1 a except that the positive effect appears only in very low concentrations and over a very narrow range. However, studies of hormesis suggest that the positive effect is a stimulation action rather than growth-promotion. Thus, note should be taken of subsequent biological effects, for instance, uncontrolled cell proliferation.
看看你想作哪方面，如果要作毒性，就加大浓度好了，如果想全面看机制，倒是可以都做做，不过很难把这个阐明清楚。文章方面，多查查关于砷的，铂的，我记得有一篇关于稀土元素的， 就是先增殖后凋亡，呵呵，记不得太清楚了，抱歉查了半天没查到。有时间再找找。
