小中大
相关疾病：
肿瘤
您的理解非常正确，现在的蛋白芯片基本上都是基于抗体抗原反应的，最常见的种类有抗体芯片（芯片上固定的是抗体，用于检测蛋白）、抗原芯片（芯片上固定的是天然蛋白、重组蛋白、多肽、细胞裂解液、组织裂解液等，用于检测抗体）。
蛋白芯片的应用根据芯片类型不同，可以用于筛选疾病标志物，肿瘤发生发展机制研究，药物作用靶点研究，蛋白新功能研究，信号通路筛选等等方面，以下提供几篇文献供有兴趣的老师同学参考。
Bernier M, Paul RK, et al.: Negative Regulation of STAT3-mediated Cellular Respiration by SirT1, Journal of Biological Chemistry 2011, JBC Papers in Press. Published on April 5, 2011 as Manuscript M110.200311.
Wang H, Brown J, et al.: Convergence of the Mammalian Target of Rapamycin Complex 1- and Glycogen Synthase Kinase 3-b–Signaling Pathways Regulates the Innate Inflammatory Response, Journal of Immunology 2011, 186:5217-5226
Kang S, Elf S, et al.: p90 Ribosomal S6 Kinase 2 Promotes Invasion and Metastasis of Human Head and Neck Squamous Cell Carcinoma Cells, Journal of Clinical Investigation 2010, 120(4):1165-1177
Raharijaona M, Le Pennec S, et al.: PGC-1-Related Coactivator Modulates Mitochondrial-Nuclear Crosstalk through Endogenous Nitric Oxide in a Cellular Model of Oncocytic Thyroid Tumours. PLoS ONE 2009, 4(11):e7964
He H, Zong Y, et al.: Sensing the Insulin Signaling Pathway with an Antibody Array, Proteomics Clinical Applications 2009, 3:1440–1450
Yalcin A, Clem B, et al.: Nuclear Targeting of 6-Phosphofructo-2-Kinase (PFKFB3) Increases Proliferation via Cyclin-dependent Kinases, Journal of Biological Chemistry 2009, 284:24223-24232
Zhong D, Liu X, et al. LKB1 Is Necessary for Akt-Mediated Phosphorylation of Proapoptotic Proteins, Cancer Research 2008, 68:7270-7277
Zhong D, Li X, et al. The Glycolytic Inhibitor 2-Deoxyglucose Activates Multiple Prosurvival Pathway Through IGF1R, Journal of Biological Chemistry 2009, 284:23225-23233
SandipRay, et al. Classification and prediction of clinical Alzheimer’s diagnosis based on plasma signaling proteins Nature Medicine 2007,13, 1359
