小中大To a mixture of K2CO3 (24.0 g, 171 mmol) in THF (50.0 mL) in a closed round bottom flask at ambient temperature was added dimethylamine, then the mixture was cooled to - 78°C. 3-Chloropropionyl chloride (3.3 mL, 34.2 mmol) as added slowly, then the reaction was stirred at ambient temperature for 18 h. The reaction was filtered, and the solvent was removed to afford the Compound 199 as a light orange oil. 3-Chloro-N,N-dimethylpropanamide。
