小中大【讨论帖】关于乙脑减毒活疫苗的担忧
相关疾病:
流行性乙型脑炎
家有小儿不满十个月,从出生至今几乎每个月,我都会带他去分管小区的“卫生防疫站”按照“国家基础计划免疫”的要求按时接种疫苗,其中第8个月接种的是“乙脑减毒活疫苗”,该疫苗由“SA14-14-2减毒株接种原代地鼠肾细胞”获得(详见:cuturl('http://baike.baidu.com/view/4096144.htm'))。
今天实验需要查找文献,发现:“A live, attenuated JEV vaccine based on the SA14-14-2 strain is licensed for use in China. More than 200 million doses of this vaccine have been delivered since 1988 with excellent record of safety and efficacy (Xin et al, 1988; Liu et al, 1997; Bista et al, 2001). However, this vaccine is produced in primary hamster kidney cells that are not approved by WHO for human vaccine production.”(见: Development of a recombinant vaccine against Japanese encephalitis.Journal of NeuroVirology, 2003,9: 421–43. DOI: 10.1080/13550280390218454)发现中国仓鼠肾细胞用于人用疫苗的生产未经WHO获批准!故对小儿接种的乙脑减毒疫苗很是担忧。关于这类疫苗的不良反应,除了说明书上标注的“少数儿童可能出现一过性发热反应,一般不超过2天,可自行缓解。偶有散在皮疹出现,一般不需特殊处理,必要时可对症治疗。”之外,大家从专业角度如何看待?