1. Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor -induced cell death in fibroblasts
Proc. Natl. Acad. Sci. USA, 97, 5405 - 5410 (2000)
2. Apoptosis Signal-regulating Kinase 1 (ASK1) Induces Neuronal Differentiation and Survival of PC12 Cells
J. Biol. Chem., 275, 9805 - 9813 (2000).
3. Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation
J. Biol. Chem., 275, 26576 - 26581 (2000).
5. Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia
FASEB J.. 14, 307-1317 (2000)
6. BIT/SHPS-1 Enhances Brain-Derived Neurotrophic Factor-Promoted Neuronal Survival in Cultured Cerebral Cortical Neurons
J. Neuroche., 75(4), 1502-1510 (2000).
7. Shp-2 Specifically Regulates Several Tyrosine-Phosphorylated Proteins in Brain-Derived Neurotrophic Factor Signal
J. Neurochem., 74(2), 659-668 (2000).
8. Inhibitory Effect of Peptide-Free Forms of Advanced Glycation Products on the Proliferation and Extracellular Matrix Protein Production of Cultured Cells
J. Health Sci., 47(3), 296-301 (2001).
9. Transcriptional Activation of the Thyroglobulin Promoter Directing Suicide Gene Expression by Thyroid Transcription Factor-1 in Thyroid Cancer Cells
Cancer Res., 61, 3640-3646 (2001)
10. Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway
Proc. Natl. Acad. Sci. USA, 98(19), 10845-10850 (2001).
11. Three vasoactive peptides, endothelin-1, adrenomedullin and urotensin-II, in human tumour cell lines of different origin: expression and effects on proliferation
Clinical Science, 103(48), 35S-38S (2002).
12. Induction of Neurite Extension and Survival in Pheochromocytoma Cells by the Rit GTPase
J. Biol. Chem., 277(23), 20160-20168 (2002).
13. An improved, simple screening method for detection of glucose-6-phosphate dehydrogenase deficiency
Tropical Medicine & International Health Volume 8 Issue 6 Page 569 - June 2003
14. Gene Transfection of H25A Mutant Heme Oxygenase-1 Protects Cells against Hydroperoxide-induced Cytotoxicity
J. Biol. Chem., 277, 10712 - 10718 (2002).
15. Human Thrombospondin 2 Inhibits Proliferation of Microvascular Endothelial Cells
Int. J. Oncol., 20, 339-342 (2002).作者: milkdog 时间: 2012-10-19 11:11
Tropical Medicine & International HealthVolume 8 Issue 6 Page 569 - June 2003doi:10.1046/j.1365-3156.2003.01055.x
An improved, simple screening method for detection of glucose-6-phosphate dehydrogenase deficiency
Indah S. Tantular1,2 and Fumihiko Kawamoto2
Summary
We established a new, simple and rapid screening method for detection of glucose-6-phosphate dehydrogenase (G6PD)-deficiency by using a new formazan substrate, 2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H tetrazolium monosodium salt (WST-8) with a hydrogen carrier of 1-methoxyphenazine methosulfate (1-methoxy PMS), instead of a combination of 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide (MTT) and phenazine methosulfate (PMS), as used in many previous formazan methods. WST-8 does not react with haemoglobin, and the formed formazan is highly water-soluble, differing from MTT. Thus, the whole procedure can be performed in aqueous solution in a tube or well without any special equipment other than micropipettes. Within 1 h at room temperature, the strong orange colour of the WST-8 formazan formed in normal blood samples could be distinguished, by naked eye, from G6PD-deficient blood samples with less than 50% residual activity. We also found that reagents in the WST-8/1-methoxy PMS method were more resistant against exposure to sunlight than those in an MTT/PMS method. As the new method is both qualitative and quantitative, it is possible to express G6PD activity as increase of NADPH concentration by reading absorbance at 460 nm after incubation for 30 or 60 min.作者: windy+++ 时间: 2012-10-19 11:28
10
Satomi Onoue, Keiichi Ohshima, Kosuke Endo, Takehiko Yajima and Kazuhisa Kashimoto PACAP protects neuronal PC12 cells from the cytotoxicity of human prion protein fragment 106-126FEBS LettersVolume 522, Issue 1-3, pp. 65-70.
cuturl('http://www1.elsevier.com/febs/427/19/33/main.pdf')
11
Jun Nakamura, Shoji Asakura, Susan D. Hester, Gilbert de Murcia, Keith W. Caldecott and James A. SwenbergPrevalent Loss of Mitotic Spindle Checkpoint in Adult T-cell Leukemia Confers Resistance to Microtubule InhibitorsJ. Biol. Chem., Vol. 277, 5187-5193, 2002
cuturl('http://www.niaid.nih.gov/dir/labs/lmm/jeang/Biblio/kasaijbc2002.pdf')
12
R Fujita and H UedaProtein kinase C-mediated cell death mode switch induced by high glucoseCell death and Differentiation (2003) 00, 1-12
cuturl('http://www.ph.nagasaki-u.ac.jp/lab/neuro/doc/mol.pharmacol./pdf_file/Publications_pdf/2003CDD10_p1336.pdf')
13
Jun Nakamura, Shoji Asakura, Susan D. Hester, Gilbert de Murcia, Keith W. Caldecott and James A. SwenbergQuantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real timeNucleic Acids Research, 2003, Vol. 31, No. 17
cuturl('http://nar.oupjournals.org/cgi/reprint/31/17/e104.pdf')作者: 66+77 时间: 2012-10-19 12:39
17.
Yuichi Hashimoto, Hong Jiang, Takako Niikura, Yuko Ito, Akari Hagiwara, Kazuo Umezawa, Yoichiro Abe, Yo***ake Murayama, and Ikuo NishimotoNeuronal Apoptosis by Apolipoprotein E4 through Low-Density Lipoprotein Receptor-Related Protein and Heterotrimeric GTPases The Journal of Neuroscience, November 15, 2000, 20(22):8401–8409.
cuturl('http://www.jneurosci.org/cgi/reprint/20/22/8401.pdf')
18.
YUICHI HASHIMOTO, TAKAKO NIIKURA, YUKO ITO, YOSHIKO KITA, KENZO TERA***A, and IKUO NISHIMOTONeurotoxic Mechanisms by Alzheimer’s Disease-Linked N141I Mutant Presenilin 2THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Vol. 300, No. 3
cuturl('http://jpet.aspetjournals.org/cgi/reprint/300/3/736.pdf')
19.
Masayasu Kimura, Yoichi Mizukami, Toshiro Miura, Kiyoko Fujimoto, Sei Kobayashi and Masunori MatsuzakiOrphan G Protein-coupled Receptor, GPR41, Induces Apoptosis via a p53/Bax Pathway during Ischemic Hypoxia and ReoxygenationJ. Biol. Chem., 276(28), 26453-26460 (2001).
cuturl('http://www.jbc.org/cgi/reprint/276/28/26453')作者: 66+77 时间: 2012-10-19 12:42
20
Issei Imoto, Zeng-Quan Yang, Atiphan Pimkhaokham, Hitoshi Tsuda, Yutaka Shimada, Masayuki Imamura, Misao Ohki, and Johji InazawaIdentification of cIAP1 As a Candidate Target Gene within an Amplicon at 11q22 in Esophageal Squamous Cell CarcinomasCANCER RESEARCH 61, 6629–6634, September 15, 2001
cuturl('http://cancerres.aacrjournals.org/cgi/reprint/61/18/6629.pdf')
21
Tetsuo Udono, Kazuhiro Takahashi, Masaharu Nakayama, Ayako Yoshinoya, Kazuhito Totsune, Osamu Murakami, Yusuf K. Durlu, Makoto Tamai, and Shigeki ShibaharaInduction of Adrenomedullin by Hypoxia in Cultured Retinal Pigment Epithelial CellsIOVS, April 2001, Vol. 42, No. 5
cuturl('http://www.iovs.org/cgi/reprint/42/5/1080.pdf')
22
Michael L. Spencer, Haipeng Shao, and Douglas A. AndresInduction of Neurite Extension and Survival in Pheochromocytoma Cells by the Rit GTPaseJ. Biol. Chem., 277(23), 20160-20168 (2002).
cuturl('http://www.jbc.org/cgi/reprint/277/23/20160?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexactfulltext=and&searchid=1081494519943_20&stored_search=&FIRSTINDEX=0&sortspec=relevance&volume=277&firstpage=20160&resourcetype=1')
23
Jeng-Long Hsieh, Chao-Liang Wu, Che-Hsin Lee, and Ai-Li ShiauHepatitis B Virus X Protein Sensitizes Hepatocellular Carcinoma Cells to Cytolysis Induced by E1B-deleted Adenovirus through the Disruption of p53 FunctionClinical Cancer Research Vol. 9, 338–345, January 2003
cuturl('http://clincancerres.aacrjournals.org/cgi/reprint/9/1/338.pdf')
24
Yasushi Tomii, Junichiro Kamochi, Hitoshi Yamazaki, Nobuko Sawa, Tetsuji Tokunaga, Yasuyuki Ohnishi, Hiroshi Kijima, Yo***o Ueyama, Norikazu Tamaoki and Masato Nakamura Human Thrombospondin 2 Inhibits Proliferation of Microvascular Endothelial Cells Int. J. Oncol., 20, 339-342 (2002).
cuturl('http://virology.med.uoc.gr/IJO/2002/volume20/number2/339-342.pdf')
不知道这些论文对你们有没有用作者: 66+77 时间: 2012-10-19 12:43
25
Michael L. Spencer, Haipeng Shao, and Douglas A. AndresInduction of Neurite Extension and Survival in Pheochromocytoma Cells by the Rit GTPaseJ. Biol. Chem., 277(23), 20160-20168 (2002).
cuturl('http://www.jbc.org/cgi/reprint/277/23/20160?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexactfulltext=and&searchid=1081494519943_20&stored_search=&FIRSTINDEX=0&sortspec=relevance&volume=277&firstpage=20160&resourcetype=1')
26
Kazuhiro Yoshihara, Tomohide Okumura, Tomonobu Yoshida and Masatoshi BeppuInhibitory Effect of Peptide-Free Forms of Advanced Glycation Products on the Proliferation and Extracellular Matrix Protein Production of Cultured CellsJ. Health Sci., 47(3), 296-301 (2001).
cuturl('http://jhs.pharm.or.jp/47')(3)/47(3)p296.pdf
27
Takako Niikura,Yuichi Hashimoto, Takashi Okamoto,Yoichiro Abe, Takashi Yasukawa, Masaoki Kawasumi, Takako Hiraki, Yoshiko Kita, Kenzo Tera***a, Keisuke Kouyama, and Ikuo NishimotoInsulin-Like Growth Factor I (IGF-I) Protects Cells from Apoptosis by Alzheimer's V642I Mutant Amyloid Precursor Protein through IGF-I Receptor in an IGF-Binding Protein-Sensitive MannerThe Journal of Neuroscience, March 15, 2001, 21:1902-1910
cuturl('http://www.jneurosci.org/cgi/reprint/21/6/1902.pdf')作者: 66+77 时间: 2012-10-19 12:43
17
Tadashi Miyamoto,Wongi Min,and Hyun S. LillehojLymphocyte Proliferation Response During Eimeria tenella Infection Assessed by a New, Reliable, Nonradioactive ColorimetricAssayAvian Diseases: Vol. 46, No. 1, pp. 10–16.cuturl('http://www.bioone.org/bioone/?request=get-abstract&issn=0005-2086&volume=046&issue=01&page=0010')
18
Yashusi Adachi, Shigeru Taketani, Junko Toki, Kazuya Ikebukuro, Kikuya Sugiura, Haruki Oyaizu yoji Yasumizu, Minoru Tomita, Hiroyuki Kaneda, Yasuo Amoh, Tomoki Ito Mitsuhiko Okigaki, Muneo Inaba, Susumu IkeharaMarked Increase in Number of Dendritic Cells in Autoimmune-Prone (NZW x BXSF1 Mice with Age Stem Cells 2002;20:61-72cuturl('http://stemcells.alphamedpress.org/cgi/reprint/20/1/61.pdf')
19
Shiro YamashojiMenadione-Catalyzed Luminol Chemiluminescent Assay for Viability of Mycobacterium bovisMicrobiol. Immunol., 46, 571—573, 2002
cuturl('http://www.sanbi.co.jp/capj/46/abs/460807.pdf')作者: 66+77 时间: 2012-10-19 12:44
1、Christopher A. Reilly, Jack L. Taylor, Diane L. Lanza, Brian A. Carr, Dennis J. Crouch, and Garold S. Yost
Capsaicinoids Cause Inflammation and Epithelial Cell Death through Activation of Vanilloid Receptors
Toxicol. Sci., May 2003; 73: 170 - 181.
2、 Edward Chaum and Huaitao Yang
Transgenic Expression of IGF-1 Modifies the Proliferative Potential of Human Retinal Pigment Epithelial Cells
Invest. Ophthalmol. Vis. Sci., Dec 2002; 43: 3758 - 3764
3、Maaria Ikonen, Bingrong Liu, Yuichi Hashimoto, Liqun Ma, Kuk-Wha Lee, Takako Niikura, Ikuo Nishimoto, and Pinchas Cohen
Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis
PNAS, Oct 2003; 100: 13042 - 13047.作者: 66+77 时间: 2012-10-19 12:44
Seongwoo Hwang, Natarajan Tamilarasu, Karen Kibler, Hong Cao, Akbar Ali, Yueh-Hsin Ping, Kuan-Teh Jeang, and Tariq M. Rana
Discovery of a Small Molecule Tat-trans-Activation-responsive RNA Antagonist That Potently Inhibits Human Immunodeficiency Virus-1 Replication
THE JOURNAL OF BIOLOGICAL CHEMISTRYOF BIOLOGICAL CHEMISTRY Vol. 278, No. 40, Issue of October 3, pp. 39092–39103, 2003
Antiretroviral therapy to treat AIDS uses molecules that target the reverse transcriptase and protease enzymes of human immunodeficiency virus, type 1 (HIV-1). A major problem associated with these treatments, however, is the emergence of drug-resistant strains. Thus, there is a compelling need to find drugs against other viral targets. One such target is the interaction between Tat, an HIV-1 regulatory protein essential for viral replication, and trans-activation-responsive (TAR) RNA. Here we describe the design and synthesis of an encoded combinatorial library containing 39,304 unnatural small molecules. Using a rapid high through-put screening technology, we identified 59 compounds. Structure-activity relationship studies led to the synthesis of 19 compounds that bind TAR RNA with high affinities. In the presence of a representative Tat-TAR inhibitor (5 microM TR87), we observed potent and sustained suppression of HIV replication in cultured cells over 24 days. The same concentration of this inhibitor did not exhibit any toxicity in cell cultures or in mice. TR87 was also shown to specifically disrupt Tat-TAR binding in vitro and inhibit Tat-mediated transcriptional activation in vitro and in vivo, providing a strong correlation between its activities and inhibition of HIV-1 replication. These results provide a structural scaffold for further development of new drugs, alone or in combination with other drugs, for treatment of HIV-1-infected individuals. Our results also suggest a general strategy for discovering pharmacophores targeting RNA structures that are essential in progression of other infectious, inflammatory, and genetic diseases.作者: 66+77 时间: 2012-10-19 12:47
Negative regulation of hepatocellular carcinoma cell growth by signal regulatory protein 1
HEPATOLOGY 2004;40:618–628.
Abstract
Signal regulatory protein (SIRP) 1 is a member of the SIRP family that undergoes tyrosine phosphorylation and binds SHP-2 tyrosine phosphatase in response to various mitogens. The expression levels of SIRP1 were decreased in HCC tissues, compared with the matched normal tissues. Exogenous expression of wild type SIRP1, but not of a mutant SIRP1 lacking the tyrosine phosphorylation sites, in SIRP1-negative Huh7 human HCC cells resulted in suppression of tumor cell growth both in vitro and in vivo. Treatment of Huh7 transfectants with EGF or HGF induced tyrosine phosphorylation of SIRP1 and its association with SHP-2, which were accompanied by reduced ERK1 activation. Expression of SIRP1 significantly suppressed activation of NF-B and also sensitized Huh7 cells to TNF or cisplatin-induced cell death. In addition, SIRP1-transfected Huh7 cells displayed reduced cell migration and cell spreading in a fashion that was dependent on SIRP1/SHP-2 complex formation. In conclusion, a negative regulatory effect of SIRP1 on hepatocarcinogenesis is exerted, at least in part, through inhibition of ERK and NF-B pathways.
cuturl('http://www3.interscience.wiley.com/cgi-bin/abstract/109606299/ABSTRACT')作者: jkobn 时间: 2012-10-19 12:47
在The Journal of cell biology（影响因子12）上发表的一篇文献：
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
J. Cell Biol., 15(2), 227-233 (2002).
cuturl('http://www.jcb.org/cgi/reprint/158/2/227.pdf')作者: 66+77 时间: 2012-10-19 12:51
介绍一个检索文献的好网站，有大量的免费文献，14,914,220 articles in over 4,500 Medline journals, 768,654 free full text articles from 696 HighWire-hosted journals
cuturl('http://highwire.stanford.edu/')作者: 66+77 时间: 2012-10-19 12:51
发表在Nature Cell Biology上的一篇文献：
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells
SUMMARY: Colorectal and hepatocellular carcinomas are some of the leading causes of cancer deaths worldwide, but the mechanisms that underly these malignancies are not fully...
CONTEXT: ...supplemented with 0.9 g l-1 geneticin (NIH3T3 and HEK293). The number of cells was measured with cell counting kit-8 (Dojindo, Kumamoto, Japan). Gene silencing effect of SMYD3 siRNAs. A psiU6BX vector was created that contained the......
Nature Cell Biology6, 731 - 740 (01 Aug 2004)
但我没有PDF文件，谁有请给我一份作者: 66+77 时间: 2012-10-19 12:51
发表在JCB上的一篇文献：
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
J. Cell Biol., 15(2), 227-233 (2002).
cuturl('http://www.jcb.org/cgi/reprint/158/2/227.pdf')作者: leifengta 时间: 2012-10-19 12:52
发表在Blood上的一篇有关文献
Mitochondrial Antisense RNA for Cytochrome C Oxidase (MARCO) Can Induce Morphologic Changes and Cell Death in Human Hematopoietic Cell Lines
Blood,Vol 90, No 11 (December 1), 1997: pp 4567-4577作者: okhaha 时间: 2012-10-19 12:55
国内研究人员发表在PNAS上的文献:
AML1-ETO and C-KIT mutation_overexpression in t(8;21) leukemia: Implication in stepwise leukemogenesis and response to Gleevec
PNAS January 25, 2005 vol. 102 1104–1109作者: 西子 时间: 2012-10-19 14:41
the IC50 (or EC50 - effective concentration 50%) is the concentration required for 50% inhibition.
the IC90 is the concentration required for 90% inhibition.作者: 西子 时间: 2012-10-19 14:44
