老孔发表了许多论文我承认，大部分都是关于癌症治疗的我也承认，但是有关cellbrain这个概念的提出是在什么时候？是在国外的时候吗？
在pubmed上搜索，cellbrain这个词汇第一次出现是在下面这片文章：
Med Hypotheses. 2002 Oct;59(4):367-72.Click here to read Links
Cell brain crystallization for cancer therapy.
Kong Q, Sun J, Kong LD.
Cocid Corp, Denver, CO 80220, USA. kongq@cellbrain.org
Cancer remains one of the leading causes of death throughout the world. One of the important reasons why conventional treatments fail is the development of resistance to therapeutics. The dual effect concept and self-defense mechanism plus the threshold theory might in part explain the development of resistance, however, the primary cause is unclear. A novel theory, 'cell brain', where, selective crystallization of the 'brain' of a cell (comprising centrosome, centrioles and the connecting filaments) occurs, may be a potential alternate approach to cancer therapy.
请问这个 Cocid Corp是个什么公司？在这里，孔教授的名字有两个单位，一个是 Cocid Corp，另外一个是济南康友医药科技有限公司。
这篇文章的收稿日期是2001年4月，这个时候孔教授应该还没有回国。
还有孔教授在文章中的联系Email是kongq@cellbrain.org，这个域名是2001年3月申请的，到现在一直正常续费。是以个人名义注册的，地址是美国丹佛799 Dahlia st. suite 502。
这些到底是怎么回事？怎么乱七八糟的？作者: 生物迷 时间: 2015-11-13 11:46
According to the American Brain Tumor Association, there are approximately 18,000 malignant gliomas diagnosed in the United States each year. Approximately 11,000-12,000 of these patients will undergo surgery to remove an original or recurrent high-grade malignant glioma.
Population of China is almost 5 times of the US.How many should be the patients who suffering malignant gliomas? You can calculate. 作者: Darcy 时间: 2015-11-13 12:01
我们假想，您的化合物花巨资、花十年时间开发成功了，然后用您的注射剂（全身给药）治疗脑肿瘤，先不说您的化合物与“卡莫司汀”相比对脑胶质瘤敏感强弱程度，也不说它受血脑屏障限制程度如何，仅就注射剂到达脑肿瘤所在部位的浓度和短暂的作用时间，您可以想象它的治疗效果；事实上您的注射剂大量作用于全身，毒副作用毋庸置疑。
卡莫司汀缓释植入剂没有上述担忧：该化合物对脑肿瘤的治疗作用敏感确切，植入剂的剂型和给药方式可以保证它不受血脑屏障的任何限制，给药后药物的释放仅在局部，药代动力学数据可以看到它体内扩散的距离非常小，释放时间近一个月。综合其对脑胶质瘤敏感、术中及时给药、局部高浓度长时间缓慢释放、不参与全身循环的特点，使本产品尽管貌不惊人，却可以达到疗效好、防止脑胶质瘤术后复发、无全身毒副作用的效果，这是医生和患者都需要的结果。您的开发十年的新化合物能做得到吗？
我们可以不加夸张地评价：它的开发远远超过您的新化合物的开发价值。如果您具备以上基本知识，如果您又是老板（但看您的修养不太可能），但万一由您立题的话
You should have same choice......Regarding brain tumor treatment, an old agent with
confirmed efficacy to be formulated into Implant will be the best choice!!!
我原以为专家们可以客观地评价本产品，正确地评价它的优势所在，
但是除了有人刀棒相加以外，没有一个对它说句公道话。不知是专家浑然不知，还是为了通过“刀砍棒追” 来发泄精神抑郁, 进而失去专家的 “浑度”........
AHHA作者: 3N4G 时间: 2015-11-13 12:01
According to the American Brain Tumor Association, there are approximately 18,000 malignant gliomas diagnosed in the United States each year. Approximately 11,000-12,000 of these patients will undergo surgery to remove an original or recurrent high-grade malignant glioma.
Population of China is almost 5 times of the US.How many should be the patients who suffering malignant gliomas? You can calculate.
6、在山东大学生命科学学院旧版网址的“学术队伍”介绍一文
（cuturl('http://www.lifesci.sdu.edu.cn/xueke/duiwu.htm')），没有“孔庆忠”和
“细胞脑”的任何信息。
7、其他信息，可以排除“孔庆忠”与山大本部、以及山大医学院的实质联系：
抱歉，没有找到与“孔庆忠 site:cuturl('www.sdu.edu.cn')” 相关的网页。（百度）
抱歉，没有找到与“孔庆忠 site:cuturl('www.medicine.sdu.edu.cn')” 相关的网页。
（百度）
抱歉，没有找到与“细胞脑 site:cuturl('www.sdu.edu.cn')” 相关的网页。
抱歉，没有找到与“细胞脑 site:cuturl('www.medicine.sdu.edu.cn')” 相关的网页。
（百度）
找不到和您的查询 "孔庆忠 site:cuturl('www.sdu.edu.cn')" 相符的网页。（google）
找不到和您的查询 "孔庆忠 site:cuturl('www.medicine.sdu.edu.cn')" 相符的网页。
（google）
找不到和您的查询 "细胞脑 site:cuturl('www.sdu.edu.cn')" 相符的网页。（google）
找不到和您的查询 "细胞脑 site:cuturl('www.medicine.sdu.edu.cn')" 相符的网页。
（google）
8、在“蓝金”网站找到山东大学聘书一份，聘期自2002年至2005年，山大聘字
02011号，系山大兼职教授。
cuturl('http://www.lanjin.cn/honor.php')
三、Medline查询“cell brain AND Kong Q”或者“cell brain AND Kong QZ”
信息，可以获得24条文献信息，去掉英文缩写同名者，一共还有15条文献信息
（注：可能有遗漏，因为新闻报道该人“在国际知名学术刊物上发表了数百篇论
文”）。另外，在全部15篇文献中，有近半数（6篇）文献均发表在“Med
Hypotheses”杂志。
1、Chen Y, Zhang N, Kong QZ.
Cell Brain Research Center, School of Life Science, Shandong University,
Jinan, Shandong, 250100, P. R. China.
[Cell brain abnormalities in carcinogenesis]
Ai Zheng. 2006 Sep;25(9):1186-90. Review. Chinese.
PMID: 16965668 [PubMed - indexed for MEDLINE]
2、Chen Y, Kong Q.
Cell Brain Research Center, South Biology Building, Room 128, Shandong
University School of Life Science, Jinan, Shandong Province 250100, PR
China.（终于找到这个中心所在地了，在山东大学生命科学院南楼128房间）
Cell brain: insight into hepatocarcinogenesis.
Med Hypotheses. 2006;67(1):44-52.
PMID: 16600524 [PubMed - indexed for MEDLINE]
3、Zhao Y, Zhang N, Kong Q.
School of Life Science, Shandong University, Jinan 250100, China.
Tetrazolium violet induces G0/G1 arrest and apoptosis in brain tumor
cells.
J Neurooncol. 2006 Apr;77(2):109-15. Epub 2005 Nov 29.
PMID: 16314959 [PubMed - indexed for MEDLINE]
4、Zhao Y, Zhang N, Kong Q.
Cell Brain Research Center, School of Life Science, Shandong University,
Room 128, Biology Building, Jinan, Shandong Province 250100, China.
（又见128房间，128，要你发？）
Does the cell-brain theory work in explaining carcinogenesis?
Med Hypotheses. 2005;65(4):708-15.
PMID: 15975733 [PubMed - indexed for MEDLINE]
5、Kong QZ, Zhang N, Zhao YF.
Cell Brain Research Center, Shandong University, Jinan, Shandong
Province, China. kongq@cellbrain.org
The roles of centrosome in cancer development.
Drug News Perspect. 2004 Apr;17(3):195-200. Review.
PMID: 15179454 [PubMed - indexed for MEDLINE]
6、Kong Q.
Cell Brain Research Center, Shandong University, Jinan, China. kongq@yahoo.com
The centrosome-centered cell-brain in apoptosis.
Med Hypotheses. 2003 Jul;61(1):126-32.
PMID: 12781655 [PubMed - indexed for MEDLINE]
7、Kong Q.
Cell Brain Research Center, Shandong University, Jinan, Shandong
Province, China. cellbrain2k@yahoo.com
Cell brain abnormalities in cancer development.
Med Hypotheses. 2003 Jul;61(1):120-5.
PMID: 12781654 [PubMed - indexed for MEDLINE]
8、Kong Q.
Cell Brain Research Center, Shandong University, Jinan, Shandong
Province, China. cellbrain2k@yahoo.com
Cell brain: a new focus in the postgenomic era.
Med Hypotheses. 2003 Jul;61(1):114-9.
PMID: 12781653 [PubMed - indexed for MEDLINE]
9、Kong Q, Sun J, Kong LD.
Cocid Corp, Denver, CO 80220, USA. kongq@cellbrain.org
Cell brain crystallization for cancer therapy.
Med Hypotheses. 2002 Oct;59(4):367-72.
PMID: 12208173 [PubMed - indexed for MEDLINE]
10、Kong Q, Kleinschmidt-DeMasters BK, Lillehei KO.
Department of Surgery, University of Colorado Health Sciences Center,
Denver 80262, USA. qing.kong@uchsc.edu
Intralesionally implanted cisplatin plus systemic carmustine for the
treatment of brain tumor in rats.
J Surg Oncol. 1998 Oct;69(2):76-82.
PMID: 9808509 [PubMed - indexed for MEDLINE]
11、Kong Q, Kleinschmidt-Demasters BK, Lillehei KO.
Department of Surgery, University of Colorado Health Sciences Center,
Denver 80262, USA
Intralesionally implanted cisplatin cures primary brain tumor in rats.
J Surg Oncol. 1997 Apr;64(4):268-73.
PMID: 9142181 [PubMed - indexed for MEDLINE]
12、Lillehei KO, Kong Q, Withrow SJ, Kleinschmidt-DeMasters B.
Department of Surgery, Colorado State University School of Veterinary
Medicine, Fort Collins, USA
Efficacy of intralesionally administered cisplatin-impregnated
biodegradable polymer for the treatment of 9L gliosarcoma in the rat.
Neurosurgery. 1996 Dec;39Devil:1191-7; discussion 1197-9.
PMID: 8938774 [PubMed - indexed for MEDLINE]
13、Kruse CA, Kong Q, Schiltz PM, Kleinschmidt-DeMasters BK.
Department of Surgery, University of Colorado Health Sciences Center,
Denver 80262.
Migration of activated lymphocytes when adoptively transferred into
cannulated rat brain.
J Neuroimmunol. 1994 Nov;55(1):11-21.
PMID: 7962481 [PubMed - indexed for MEDLINE]
14、Kruse CA, Schiltz PM, Bellgrau D, Kong Q, Kleinschmidt-DeMasters BK.
University of Colorado Health Sciences Center, Department of Surgery,
Denver
Intracranial administrations of single or multiple source allogeneic
cytotoxic T lymphocytes: chronic therapy for primary brain tumors.
J Neurooncol. 1994;19(2):161-8.
PMID: 7964992 [PubMed - indexed for MEDLINE]
15、Kruse CA, Mitchell DH, Kleinschmidt-DeMasters BK, Bellgrau D, Eule
JM, Parra JR, Kong Q, Lillehei KO.
Department of Surgery, University of Colorado Health Sciences Center,
Denver 80262
Systemic chemotherapy combined with local adoptive immunotherapy cures
rats bearing 9L gliosarcoma.
J Neurooncol. 1993 Feb;15(2):97-112.
PMID: 8509824 [PubMed - indexed for MEDLINE]
四、查询whois，得到关于CELLBRAIN.ORG的信息如下：
Domain Name:CELLBRAIN.ORG
Created On:25-Mar-2001 02:42:36 UTC
Last Updated On:15-Mar-2008 05:21:34 UTC
Expiration Date:25-Mar-2009 02:42:36 UTC
Sponsoring Registrar:Melbourne IT, Ltd. dba Internet Names Worldwide
(R52-LROR)作者: bojitu 时间: 2015-11-13 12:05
