小中大
Proteomics is money consuming. Simple protein comparison can not yield too much useful information, but attract fundings or grants. Most of paper published only disclosure the differences on high abundance proteins, which may be the result of change not the root cause. A paper may claim 30-50 proteins difference, but non of them can be verified by biology.
Protein identification techniques are quite mature, especially MS part. The challenging part of proteomics is how to find differentially expressed proteins. If proteomics can not combined with genomics, the research is less useful, even useless. The instruments are very good, but the problem is that operators don't know research and researchers don't know what is the right tools to choose.
