小中大回复 #1 chiraler 的帖子
Ethoxynonafluorobutane (ENFB)，米有用过，第一次听说，Bai du & Google了一下，原来是这么个试剂：
1-ethoxy-1,1,2,2,3,3,4,4,4-nonafluorobutane (C4F9OC2H5)
1-乙氧基-1,1,2,2,3,3,4,4,4-九氟丁烷
PubMed一查，还真有人用来做手性分析，作为环境友好型的正己烷替代物使用（an environmentally friendly solvent ，as hexane alternative），自己平常只用过正己烷-异丙醇/无水乙醇体系做正相手性分离，借机了解学习一下，O(∩_∩)O~
1: Development and implementation of a stereoselective normal-phase liquid chromatography-tandem mass spectrometry method for the determination of intrinsic metabolic clearance in human liver microsomes.
Zhang Y, Caporuscio C, Dai J, Witkusa M, Rose A, Santella J, D'Arienzo C, Wang-Iverson DB, Tymiak AA.
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Nov 1;875(1):154-60.
2: Optimization of normal-phase chromatographic separation of compounds with primary, secondary and tertiary amino groups.
Kagan M, Chlenov M, Melnikov S, Greenfield A, Gross J, Bernotas RC.
J Chromatogr A. 2008 Jun 13;1194(1):80-9. Epub 2008 Apr 24.
3: Normal-phase chiral liquid chromatography-mass spectrometry of non-UV-active compounds: applications for pharmaceutically relevant racemates.
Kagan M, Chlenov M, Greenfield A, Ho DM.
J Chromatogr A. 2006 Jul 7;1120(1-2):82-8. Epub 2006 Jan 30.
4: Evaluation of ethoxynonafluorobutane as a safe and environmentally friendly solvent for chiral normal-phase LC-atmospheric pressure chemical ionization/electrospray ionization-mass spectrometry.
Ding J, Desai M, Armstrong DW.
J Chromatogr A. 2005 May 27;1076(1-2):34-43.
5: Normal-phase high-performance liquid chromatographic separations using ethoxynonafluorobutane as hexane alternative. II. Liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry applications with methanol gradients.
Kagan M, Chlenov M, Kraml CM.
J Chromatogr A. 2004 Apr 16;1033(2):321-31.
6: Normal-phase high-performance liquid chromatographic separations using ethoxynonafluorobutane as hexane alternative. I. Analytical and chiral applications.
Kagan MZ.
J Chromatogr A. 2001 May 25;918(2):292-302.
cuturl('http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=ETHOXYNONAFLUOROBUTANE&itool=QuerySuggestion')
曾有达人用Ethoxynonafluorobutane (ENFB)做手性分析（Ph.D.Dissertations），老板是大名鼎鼎的Prof. Daniel W. Armstrong
Enantiomeric chromatographic separations and ionic liquids
by Ding, Jie, Ph.D., Iowa State University, 2005, 185 pages; AAT 3200412
cuturl('http://proquest.umi.com/pqdlink?did=1068223361&Fmt=7&clientI') d=79356&RQT=309&VName=PQD
