小中大
如果你详细看看上边摘要，就知道在这句话中：＂The cultured
cells showed an enhanced expression of receptor activator of nuclear factor jB ligand (RANKL) and a decreased expression of
osteoprotegerin (OPG).＂，"the cultured cells" 没有说是破骨细胞．
如果你再去读该文章的813页，你就彻底明白了：OPN enhances the RANKL expression and suppresses the OPG expression on stromal cells:
Because the harvested cells from joints were a heterogeneous
mixture of cells derived from multiple sources,
such as stromal cells, osteoclast precursors, and lymphocytes,
etc., there are limitations in evaluating mRNA
expression. To clarify the effect of OPN on the expression
of RANKL and OPG, we used a murine stromal
cell line, ST2. As positive control, we used 1,25(OH)2D3
and Dex, which are well-known agents that induce
stromal cells to express RANKL and reduce their expression
of OPG [3,4,8,12,19]. While the combination of.....
