小中大
在文献中看到这一句，百思不得其解，向大家请教一下。Cells treated with chloroquineþ+epirubicin showed high levels of accumulated LC3BII protein, indicating that autophagic flux is inhibited in these cells and may at least in part contribute to the observed reduction in viability。从氯喹的抑制自噬的机理方面，我是这样理解的：氯喹破坏溶酶体的功能抑制自噬，所以LC3B-II在细胞内堆积。可是这篇文献前面检测细胞株的基础自噬水平时也提到，increased levels of LC3B-II in the presence of bafilomycin A1 indicated that epirubicin treatment induces autophagic flux。那到底LC3B-II升高是提示自噬发生了还是被抑制了？
