液相色谱

看一文章中写道
Figure 1 also shows “solvent front” retention factor values (kSF) which have been calculated based on retention times of the leading edge of the solvent peaks. Note that, for the strongest solvent (THF), a significant portion of the most analytically useful k range resides within the “presolvent-front” region of the chromatogrambetween t0 and tSF.

请问这个Ksf是什么时间，可见和死时间是不同的

For THF, the solvent front is beyond the time scale of the chromatogram (7.59min).

“……calculated based on retention times of the leading edge of the solvent peaks. ”通过溶剂峰的前沿的保留时间来算的，具体怎么算没说。

应该是一个衡量溶剂前沿保留时间的参数，理论上溶剂前沿只和柱体积有关，实际上也会和具体溶剂有关，比如同体积甲醇，乙腈，THF等和同量水混溶后的体积都不一样。对一般分析没问题，可能对于精密分析有所影响吧